BDBM98891 US8497265, 217::US8497265, 239

SMILES OCC1CCN(CC1)c1nccnc1OC1CN(C1)c1ccc2ccccc2n1

InChI Key InChIKey=VIXNRMUNIQTMQR-UHFFFAOYSA-N

Data  13 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 98891   

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Amgen

US Patent
LigandPNGBDBM98891(US8497265, 217 | US8497265, 239)
Affinity DataIC50:  2.30nMAssay Description:Enzyme activity: An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale, Calif). More data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Amgen

US Patent
LigandPNGBDBM98891(US8497265, 217 | US8497265, 239)
Affinity DataIC50:  23.3nMAssay Description:Enzyme activity: An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale, Calif). More data for this Ligand-Target Pair
LigandPNGBDBM98891(US8497265, 217 | US8497265, 239)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of human PDE10A using FAM-cAMP substrate by TR-FRET progressive binding assayMore data for this Ligand-Target Pair
LigandPNGBDBM98891(US8497265, 217 | US8497265, 239)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of human PDE10A2 using FAM-cAMP substrate by TR-FRET progressive binding assayMore data for this Ligand-Target Pair